Hepatoprotective activity of silymarin in carbontetrachloride (ccl4)–intoxicated rats

Ayeni G., Ejoba R., Olajide, J.E and Olupinyo S

Hepatoprotective property of silymarin at graded doses (40, 60 and 80 mg/kg body weight) was investigated using the model of CCl4-induction in wistar strain of albino rats. Significant (p<0.05) rise in the serum levels of transaminases (alanine and aspartate amino transaminases), alkaline phosphatase, total bilirubin and lipid peroxide values were observed in the liver of rats group treated with CCl4. However, there were sharp decrease in the serum activity of the transaminases, alkaline phosphatase, total bilirubin and peroxide values on the administration of silymarin at different doses and a concomitant increase in the serum levels of  albumin, vitamin C and catalase  activity significantly (p<0.05) different from experimental group treated with  CCl4 only. Balanced in the serum equilibrium levels in all the groups of experimental rats treated simultaneously with CCl4 and silymarin to that effects, similar to what were experienced in liquid paraffin administered (at 1ml/kg body weight) (control) group. This observation attest to the fact that, silymarin though in its lowest doses could still retain  its hepatoprotective and  therapeutic potential on the liver against  exogenous toxic onslaught.

Download PDF: